Molecular Playground/MMP12

MMP12
MMP12 is a member of matrix metalloproteinases (MMPs)which are zinc-dependent endopeptidases. They are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. The MMPs are inhibited by specific endogenous tissue inhibitor of metalloproteinases (TIMPs). Here, the complexation between catalytic domain of human MMP12 and the inhibitor (R)-2-(biphenyl-4-ylsulfonamido)-4-methylpentanoic acid is shown.

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